荜拔酰胺的结构修饰与生物活性研究进展

范思琪, 方方

中国药学杂志 ›› 2020, Vol. 55 ›› Issue (6) : 413-420.

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中国药学杂志 ›› 2020, Vol. 55 ›› Issue (6) : 413-420. DOI: 10.11669/cpj.2020.06.001
综述

荜拔酰胺的结构修饰与生物活性研究进展

  • 范思琪1, 方方1,2*
作者信息 +

Structural Modification and Biological Activity of Piperlongumine

  • FAN Si-qi1, FANG Fang1,2*
Author information +
文章历史 +

摘要

荜拔酰胺为叔胺型酰胺类生物碱,该成分主要存在于胡椒科植物长柄胡椒以及瘤突变胡椒等的根中。荜拔酰胺具有抗血小板聚集、抗炎和抗肿瘤等多种药理活性,其衍生物也具有多种多样的活性。笔者综述了荜拔酰胺的结构修饰及其生物活性的研究进展,为荜拔酰胺类化合物的进一步研究提供参考。

Abstract

The piperlongumine is a tertiary amine amide alkaloid, which is mainly found in the roots of the Piper family like long piper (Piper longum L.) and tumor-like piper (Piper tuberculatum Jacq). It has a variety of pharmacological activities, such as anti-platelet aggregation, anti-inflammatory and anti-tumor and its derivatives also have a variety of activities. In this paper, the research progress on the structural modification and bioactivity of pharmacological effects of the piperlongumine amide is reviewed, which provides a reference for the further study of amides.

关键词

荜拔酰胺 / 结构修饰 / 生物活性

Key words

piperlongumine / structural modification / biological activity

引用本文

导出引用
范思琪, 方方. 荜拔酰胺的结构修饰与生物活性研究进展[J]. 中国药学杂志, 2020, 55(6): 413-420 https://doi.org/10.11669/cpj.2020.06.001
FAN Si-qi, FANG Fang. Structural Modification and Biological Activity of Piperlongumine[J]. Chinese Pharmaceutical Journal, 2020, 55(6): 413-420 https://doi.org/10.11669/cpj.2020.06.001
中图分类号: R914   

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基金

安徽省高校优秀青年人才支持计划重点项目资助(gxyqZD2016129)
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